Anti-Inflammatory -Kaurane Diterpenoids from .

Ten new -kaurane diterpenoids, including two pairs of epimers / and / and a 6,7---kauranoid , were obtained from the aerial parts of . The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds and exhibited notable NO production inhibition with IC values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.