Exposure to toxic metals and metalloids (TMs) such as arsenic and lead at levels of concern is associated with lifelong adverse health consequences. As exposure to TMs from paint, leaded gasoline, canned foods, and other consumer products has decreased in recent decades, the relative contribution of drinking water to environmental TM exposure and associated disease burdens has increased. We conducted a rapid review from June to September 2019 to synthesize information on the sources of TM contamination in small rural drinking water systems and solutions to TM contamination from these sources, with an emphasis on actionable evidence applicable to small rural drinking water systems worldwide. We reviewed publications from five databases (ProQuest, PubMed, Web of Science, Embase, and Global Health Library) as well as grey literature from expert groups including WHO, IWA, and others; findings from 61 eligible review publications were synthesized. Identified sources of TMs in included studies were natural occurrence (geogenic), catchment pollution, and corrosion of water distribution system materials. The review found general support for preventive over corrective actions. This review informs a useful planning and management framework for preventing and mitigating TM exposure from drinking water based on water supply characteristics, identified contamination sources, and other context-specific variables.
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http://dx.doi.org/10.3390/ijerph17197076 | DOI Listing |
Chemosphere
January 2025
Faculty of Engineering, Hokkaido University, N13W8, Sapporo, 060-8628, Japan. Electronic address:
Global concern regarding transformation products (TPs) derived from contaminants, including pesticides, in the environment and during water treatment has been growing markedly. In the present study, we investigated the anti-acetylcholinesterase (AChE) activity of an aqueous solution of the organophosphorus insecticide disulfoton, a toxicological endpoint for determining the acceptable daily intake of disulfoton, both in the presence and the absence of metabolism during chlorination. Disulfoton rapidly reacted with free chlorine and completely disappeared within 0.
View Article and Find Full Text PDFJ Occup Environ Hyg
January 2025
Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
With mines extending deeper and rising surface temperatures, workers are exposed to hotter environments. This study aimed to characterize heat stress and strain in the Canadian mining industry and evaluate the utility of the Heat Strain Score Index (HSSI), combined with additional self-reported adverse health outcomes. An exploratory web-based survey was conducted among workers ( = 119) in the Canadian mining industry.
View Article and Find Full Text PDFTissue Eng Regen Med
January 2025
Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, 07804, South Korea.
Background: Exogenous Cushing's syndrome, which results from prolonged glucocorticoid treatment, is associated with metabolic abnormalities. Previously, we reported the inhibitory effect of tonsil-derived mesenchymal stem cell conditioned medium (T-MSC CM) on glucocorticoid signal transduction. In this study, we investigated the therapeutic efficacy of T-MSCs in a mouse model of exogenous Cushing's syndrome.
View Article and Find Full Text PDFEnviron Geochem Health
January 2025
Environment Research Laboratory, Faculty of Science, Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Nepal.
A comprehensive hydrogeochemical analysis of 156 groundwater samples (106 shallow and 50 deep) was conducted in the Kathmandu Valley, Nepal. This study addresses a significant research gap by focusing on the hydro-geochemical composition and contamination of groundwater in the Kathmandu Valley, an area with limited detailed assessments. The novelty of this work lies in its comprehensive analysis of both shallow and deep groundwater, particularly concerning the high concentration of contaminants like arsenic, microbial pathogens, and ammonium, which are critical for public health.
View Article and Find Full Text PDFUrol Res Pract
January 2025
Department of Pharmacology, Ankara University, Faculty of Pharmacy, Ankara, Türkiye.
Objective: To investigate the effects of testosterone (T) treatment, with or without levothyroxine, the most widely used and least effective medication for managing hypothyroidism, on the functional and histological changes in propylthiouracil (PTU)- induced hypothyroid rat bladders.
Methods: Male rats (n=35) were split into control, hypothyroid, hypothyroid rats treated with levothyroxine (20 µg/kg/day, oral, 2-weeks), hypothyroid rats treated with Sustanon (10 mg/kg,iIM, once/week, 2-weeks), and hypothyroid rats treated with combined treatment groups. Hypothyroidism was induced by PTU (0.
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