AI Article Synopsis
- - NK cells are part of the innate immune system and have the ability to recognize and kill cancer cells, playing a crucial role in the body's defense against tumors.
- - Research is enhancing our understanding of how NK cells change in cancer patients, revealing the importance of these alterations in immune evasion by cancers.
- - The review discusses the types of NK cell changes that help cancer escape immune detection and explores strategies to boost NK cell effectiveness in cancer treatments, such as drug enhancements and genetic modifications.
Article Abstract
NK cells are innate immune cells with inherent capabilities in both recognizing and killing cancer cells. NK cell phenotypes and functional alterations are being described with increasing precision among patients harboring various cancer types, emphasizing the critical role that NK cells play in antitumor immune responses. In addition, advances in understanding NK cell biology have improved our knowledge of such alterations, thereby expanding the potential exploitation of NK cells' anticancer capabilities. In this review, we present an overview of (1) the various types of NK cell alterations that may contribute to immune evasion in cancer patients and (2) the various strategies to improve NK cell-based anticancer immunotherapies, including pharmacologic modulation and/or genetic modification.
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| http://dx.doi.org/10.1002/JLB.5MR0920-198RR | DOI Listing |
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