Herein, we report an efficient Brønsted acid-catalyzed formal (3+3)-annulation of (aza)--quinone methides generated in situ from propargylic alcohols with naphthol derivatives, which involves a 1,8-conjugate addition/6-endo annulation process. This protocol provides an effective method for preparing important functionalized pyranocoumarins under mild conditions.
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| http://dx.doi.org/10.1021/acs.joc.0c01791 | DOI Listing |
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