Comprehensive Analysis of the Expression and Prognosis for in Breast Carcinoma.

Secreted frizzled-related proteins () are a group of five secreted glycoproteins-, , (frizzled related protein), , and -which contain a frizzled-related cysteine-rich domain and a netrin module. We analyzed ' expression levels, mutations, regulation, functional networks, and correlation with immune infiltration in breast cancer (BC) patients using data from multiple open databases. were downregulated and was upregulated in BC patients compared to healthy controls. Furthermore, higher levels of were significantly associated with favorable prognosis. In addition, the prognostic significance of the infiltrating B cells was correlated to the . Based on these findings, we hypothesize that play a synergistic role in BC progression, and are, therefore, promising prognostic biomarkers as well as therapeutic targets.