AI Article Synopsis
- The study investigates serum zonulin, a marker for intestinal permeability, in patients with primary hyperparathyroidism (PHPT) compared to healthy controls.
- Findings show significantly higher zonulin levels in the PHPT group, with a strong correlation between zonulin and both parathormone (PTH) and calcium levels.
- The increase in zonulin may indicate its role in hypercalcemia development in PHPT patients.
Article Abstract
Purpose: To evaluate the serum level of zonulin, which is an intestinal permeability (IP) biomarker, in primary hyperparathyroidism (PHPT) and to investigate the relationship between zonulin, calcium, and parathormone (PTH) levels.
Methods: The study included 34 healthy control (HC) and 39 patients with PHPT. Serum calcium, phosphorus, magnesium, creatinine, albumin, and 24 h urine calcium levels were measured in all groups. Serum levels of zonulin were measured quantitatively by enzyme-linked immunosorbent assay (ELISA). Urinary ultrasonography (to assess the presence of nephrolithiasis) and dual energy X-ray absorptiometry (to assess the presence of osteoporosis) were used to evaluate complications related to PTHP.
Results: Serum zonulin levels were significantly higher in the PHPT group than the HC group (p < 0.001). Zonulin levels were significantly positively correlated with plasma PTH and serum calcium levels (r = 0.600, p < 0.001 and r = 0.610, p < 0.001; respectively). There was no correlation between serum zonulin levels and adenoma volume.
Conclusion: Serum zonulin level increases in patients with PHPT. Serum zonulin levels show a moderate/strong positive correlation with serum calcium and plasma PTH levels. This suggests that IP increase may play a role in the development of hypercalcemia in patients with PHPT.
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| http://dx.doi.org/10.1007/s12020-020-02504-0 | DOI Listing |
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