AI Article Synopsis
- The study aimed to explore if idarubicin (IDR) causes oxidative DNA damage when combined with copper (II).
- Methods involved assessing DNA damage using pBR322 plasmid DNA cleavage and measuring oxidative stress markers like O and 8-hydroxy-2'-deoxyguanosine (8-OHdG).
- Results showed that IDR does indeed induce oxidative DNA damage in the presence of copper (II), which could have implications for cancer treatment, especially since copper levels are often higher in cancer patients.
Article Abstract
Background/aim: The aim of the present study was to investigate whether idarubicin (IDR) induces oxidative DNA damage in the presence of copper (II).
Materials And Methods: DNA damage was evaluated by pBR322 plasmid DNA cleavage. The formation of oxidative stress markers [O and 8-hydroxy-2'-deoxyguanosine (8-OHdG)] was analysed.
Results: IDR induced DNA damage and O and 8-OHdG generation in the presence of copper (II).
Conclusion: IDR induced oxidative DNA damage in the presence of copper (II). Since it has been reported that the concentration of copper in the serum of cancer patients is higher than that in healthy groups, IDR-induced oxidative DNA damage in the presence of copper (II) may play an important role in anticancer therapeutic strategies.
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| http://dx.doi.org/10.21873/anticanres.14548 | DOI Listing |
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