AI Article Synopsis
- - Dengue has been a persistent issue in Nepal since 2004, with significant outbreaks, including one in 2019 that reported over 14,000 cases and six fatalities, especially affecting urban areas like Kathmandu.
- - In a study of 451 dengue patients, symptoms included fever, body ache, and a notable decrease in platelets, with 57% testing positive for the dengue virus through RNA detection.
- - The research identified DENV-2 as the predominant serotype during the 2019 outbreak, indicating crucial information for improving disease control and understanding the virus's behavior in the region.
Article Abstract
Background: Dengue cases have been continuously reported in Nepal, including some large outbreaks, since its first introduction in 2004. The disease is now expanding towards newer locations above 1400 m high, especially the country's capital city, Kathmandu. In 2019, >14,000 dengue cases including six deaths were reported. This study was aimed at the detection and molecular characterization of dengue virus (DENV) in dengue patients.
Methods: A total of 451 patients were enrolled in this study. Demographic, clinical and laboratory information was collected from dengue patients. Dengue infection was confirmed by antibody/antigen detection assays followed by RT-PCR analysis.
Results: The DENV patients showed fever, body ache, headache, myalgia, retro-orbital pain and arthralgia. The platelets were decreased, serum liver enzymes were increased and leucopenia was seen. Out of 195 patients, 111 (57.0%) were positive for DENV RNA by consensus PCR. We found DENV-2, 70 (63.1%) as the predominant serotype responsible for the 2019 outbreak, while DENV-3 was detected in two patients.
Conclusion: Our findings suggest that DENV-2 was the major serotype causing the 2019 massive outbreak in Nepal. This information will help in disease control programs to understand the molecular epidemiology and its changing trend.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/trstmh/traa096 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incidence of Guillain-Barré syndrome in Cuba before and during the Oropouche virus emergency, 2018-2024.
J Neurol
January 2025
Research, Diagnosis and Reference Center, PAHO/WHO Collaborating Center for the Study of Dengue and Its Control, Institute "Pedro Kourí", Havana, Cuba.
Early insights of dengue virus serotype 3 (DENV-3) re-emergence in São Paulo, Brazil.
J Clin Virol
January 2025
Departmento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:
Background: In dengue hyperendemic regions, the evolution of the virus is marked by frequent virus introduction/reintroduction and clade replacement events, occasionally linked to an epidemic outbreak. From 2023 onwards, an increase in the detection of DENV-3 cases has been reported in different regions of Brazil. Thus, molecular and genomic surveillance of circulating DENV strains is crucial for public health preparedness and response efforts for the disease.
View Article and Find Full Text PDFEpidemiological and cluster characteristics of dengue fever in Yunnan Province, Southwestern China, 2013-2023.
BMC Infect Dis
January 2025
Yunnan Institute of Endemic Diseases Control and Prevention, Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Dali, Yunnan, 671000, China.
Background: Yunnan Province, located in the southwestern part of China and neighboring endemic dengue regions of Southeast Asia, has experienced annual autochthonous outbreaks of dengue fever from 2013 to 2023. This study examines the epidemiological and spatiotemporal clustering characteristics of dengue within the province.
Methods: Descriptive epidemiological methods were used to analyse outbreak characteristics.
Predicting dengue incidence in high-risk areas of China through the integration of Southeast Asian and local meteorological factors.
Ecotoxicol Environ Saf
January 2025
Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, PR China.
Dengue, a climate-sensitive mosquito-borne viral disease, is endemic in many tropical and subtropical areas, with Southeast Asia bearing the highest burden. In China, dengue epidemics are primarily influenced by imported cases from Southeast Asia. By integrating monthly maximum temperature and precipitation from Southeast Asia and local provinces in China, we aim to build models to predict dengue incidence in high-risk areas of China.
View Article and Find Full Text PDFCo-infection of Dengue and hepatitis A virus among pediatric population: A study from a tertiary care center in central India during 2022-2023.
J Vector Borne Dis
January 2025
State Virology Laboratory, Department of Microbiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
Background Objectives: Co-infection of dengue virus and acute hepatitis A virus in paediatric population is a major health concern in endemic countries. This cross sectional retrospective study was conducted to evaluate the prevalence of hepatitis A virus among the clinically dengue suspected paediatric cases presented at our tertiary care centre during the two-year period (2022-2023).
Methods: A total of 747 dengue suspected paediatric clinical specimens were included in this study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!