Cryptococcoid Sweet Syndrome: A Clinical and Histologic Imitator of Cryptococcosis.

Actas Dermosifiliogr (Engl Ed)

Cátedra de Dermatología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República Oriental del Uruguay (UDELAR), Montevideo, Uruguay.

Published: January 2021

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http://dx.doi.org/10.1016/j.ad.2019.03.022DOI Listing

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Cryptococcoid Sweet syndrome (cSS) is a recently described clinical and histological variant of Sweet syndrome (SS). Its cutaneous presentation is similar to the classical form of SS but it includes atypical findings, such as capsular and yeast-like structures on microscopy that are reminiscent of species. However, in cSS, fungal staining and cultural examination are negative, whereas myeloperoxidase (MPO) staining on biopsy specimens is typically positive.

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  • - Cryptococcoid Sweet syndrome is a rare skin condition resembling classic Sweet syndrome but includes yeast-like structures in tissue samples, suggestive of fungal infection.
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Iododerma is an uncommon dermatosis caused by excessive iodine exposure and is associated with significant morbidity and mortality. Because of its heterogenous clinical presentation and variable histopathological findings, which depend on the time the skin biopsy is performed, the diagnosis of iododerma is often delayed. We report a rare case of acute iododerma in a woman with end-stage diabetic nephropathy with antecedent radioiodine contrast exposure, presenting histopathologically as cryptococcoid neutrophilic dermatosis (CND).

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