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Sequence analysis of the 5' region of the chymotrypsin C (CTRC) gene in chronic pancreatitis.
Pancreatology
January 2025
Center for Gastroenterology, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary; Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Translational Pancreatology Research Group, Szeged, Hungary. Electronic address:
Background/objectives: Loss-of-function chymotrypsin C (CTRC) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5' upstream region that includes the promoter might affect CTRC expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.
View Article and Find Full Text PDFSchistosoma mattheei and zoonotic schistosomiasis.
Trends Parasitol
January 2025
Malawi-Liverpool-Wellcome Research Programme, Kamuzu University of Health Sciences, Queen Elizabeth Central Hospital Campus, Blantyre 3, Malawi.
We highlight the epidemiological importance of Schistosoma mattheei, a common parasite of livestock with an underappreciated ability to infect people, being recently incriminated in both female and male genital schistosomiasis. Through hybridisation(s) with other schistosome species, its public health importance will grow as its zoonotic potential expands across southern Africa.
View Article and Find Full Text PDFPrediction of refraction error after toric lens implantation with biometric input data uncertainties and power labelling tolerances: Response.
Clin Exp Ophthalmol
January 2025
Department of Experimental Ophthalmology, Saarland University, Homburg, Germany.
Transdiagnostic conceptualization of schizophrenia and autism spectrum disorder. An integrative framework of minimal self disturbance.
Neuropsychopharmacol Hung
December 2024
Pszichiátriai és Pszichoterápiás Klinika, Semmelweis Egyetem, Budapest.
Article Synopsis
- The study suggests that autism spectrum disorder and schizophrenia may share overlapping features, particularly regarding minimal self-experience, characterized by altered body ownership and agency.
- A literature review highlighted tools used to assess self-experience in both disorders, revealing that minimal self-disturbances are significant in both, though they manifest differently.
- The findings indicate that these disorders might be part of a shared psychopathological continuum, with common neural mechanisms contributing to self-disturbances across the conditions.
Investigating the Role of TNF-Alpha through Blood-Brain Barrier Integrity in Stress-Induced Depression.
Neuropsychopharmacol Hung
December 2024
Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University, Budapest, Hungary.
Background: Major depressive disorder (MDD) is a complex psychiatric condition significantly impacted by environmental stress and inflammation. Previous research suggests that stress-induced alterations in the blood-brain barrier (BBB) may allow pro-inflammatory cytokines like interleukin-6 (IL-6) to enter the brain, contributing to depression. Tumor necrosis factor-alpha (TNF-α) is another prominent cytokine implicated in depression, but its role in the context of BBB integrity and stress-mediated depression remains unclear.
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