AI Article Synopsis
- - Over 35 fur colors are known in American minks, but only six have specific genetic links; Moyle fur color, which is a brownish hue, complicates breeding efforts due to its similarity to other colors.
- - Whole genome sequencing of two minks with different fur phenotypes revealed two mutations in the RAB38 gene, which is important for melanin production and melanosome development.
- - The findings emphasize RAB38's role in fur color variation and can help mink breeders select for desirable fur traits in their breeding programs.
Article Abstract
Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522971 | PMC |
| http://dx.doi.org/10.1038/s41598-020-72239-5 | DOI Listing |
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