Can the neutrophil-lymphocyte ratio predict type 1 hereditary angioedema attacks?

Scand J Clin Lab Invest

Department of Internal Medicine and Haematology, Adana City Education and Research Hospital, Yüreğir, Turkey.

Published: December 2020

The neutrophil-lymphocyte ratio is a simple and easily used parameter for the assessment of inflammation. We aimed to determine the predictive potential of the neutrophil-lymphocyte ratio regarding episode occurrence in patients with hereditary angioedema. Sixty-six patients with Type 1 hereditary angioedema and 60 healthy controls were included in the study. The laboratory results of the patients in their episode-free periods were similar to those of the healthy controls. The median of neutrophil-lymphocyte ratio was higher during episodes when compared to normal periods (3.5 versus 2.0,  < .001). A significant positive correlation was present between the episode count and the neutrophil-lymphocyte ratio calculated during the episodes ( = 0.557,  < .001). We can conclude that the neutrophil-lymphocyte ratio, which is cheap and easy to calculate, can be used by clinicians as a predictive parameter for prediction of the episode count in patients with hereditary angioedema.

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http://dx.doi.org/10.1080/00365513.2020.1827288DOI Listing

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