A first episode of psychosis (FEP) can derail a patient's educational goals, including attainment of a college education, and this can have lasting ramifications for socioeconomic and health outcomes. Despite this, few studies have examined return to college, which is an important index of real-world educational success after a FEP. In this study, we conducted a longitudinal medical record review of patients in a transdiagnostic outpatient FEP program and performed survival analysis, setting return to college as the endpoint, among the subset of patients whose college education was interrupted. We found that 82% (93/114) of college-enrolled FEP individuals experienced disruptions to their education after FEP, but that return to college also occurred in a substantial proportion (49/88, 56%) among those on leave who had follow-up data. In this sample, the median time to college return was 18 months. When separated by baseline diagnostic category, FEP patients with affective psychotic disorders (FEAP, = 45) showed faster time to college return than those with primary psychotic disorders (FEPP, = 43) (median 12 vs 24 mo; = .024, unadjusted). When adjusted for having no more than 1 psychiatric hospitalization at intake and absence of cannabis use in the 6 months prior to intake (which were also significant predictors), differences by diagnostic category were more significant (hazard ratio 2.66, 95% CI 1.43-4.94, = .002). Participation in education is an important outcome for stakeholders, and students with FEP be successful in accomplishing this goal.
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http://dx.doi.org/10.1093/schizbullopen/sgaa041 | DOI Listing |
Respir Physiol Neurobiol
December 2024
Department of Biology, Bates College, Lewiston, ME 04240.
Chronic hyperoxia during early postnatal development depresses breathing when neonatal rats are returned to room air and causes long-lasting attenuation of the hypoxic ventilatory response (HVR). In contrast, little is known about the control of breathing of juvenile or adult mammals after chronic exposure to moderate hyperoxia later in life. Therefore, Sprague-Dawley rats were exposed to 60% O for 7 days (juveniles) or for 4 and 14 days (adults) and ventilation was measured by whole-body plethysmography immediately after the exposure or following a longer period of recovery in room air.
View Article and Find Full Text PDFReprod Biomed Online
October 2024
CellOxess Biotechnology, Research and Development, Ewing, NJ, USA.
The importance of oxidative stress in the aetiology of male infertility has occasioned numerous clinical trials designed to assess the potential of antioxidants for treating this condition. These trials have not returned definitive results, probably because they have never selected participants on the basis of oxidative stress. Clearly, if a moderate to severe state of oxidative stress does not exist in semen, antioxidants can hardly be expected to improve fertility.
View Article and Find Full Text PDFGenet Med
December 2024
Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA; The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
Purpose: Genomic sequencing of newborns (NBSeq) can initiate disease surveillance and therapy for children, and may identify at-risk relatives through reverse cascade testing. We explored genetic risk communication and reverse cascade testing among families of newborns who underwent exome sequencing and had a risk for autosomal dominant disease identified.
Methods: We conducted semi-structured interviews with parents of newborns enrolled in the BabySeq Project who had a pathogenic or likely-pathogenic (P/LP) variant associated with an autosomal dominant (AD) childhood- and/or adult-onset disease returned.
J Mol Histol
December 2024
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.51, Weiliu Road, Jinan, Shandong Province, 250021, China.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an important environmental pollutant that disturbs the immune balance of the maternal-fetal interface (MFI) and is also a common environmental factor for the formation of cleft palate (CP). Therefore, the purpose is to investigate whether TCDD can cause CP by disrupting the immune balance of the maternal-fetal interface. Fifteen C57BL/6J mice were randomly assigned to three groups: control group, TCDD group, and TCDD plus Freund's complete adjuvant (FCA) (TCDD + FCA) group.
View Article and Find Full Text PDFJ Environ Manage
December 2024
Key Laboratory of Karst Georesources and Environment (Guizhou University), Ministry of Education, Guiyang, 550025, China.
Returning raw straw to the soil can significantly elevate soil methylmercury (MeHg) and crop mercury (Hg) levels, underscoring the need to investigate safer approaches to straw utilization in mercury-contaminated regions. In this study, rice straw underwent anaerobic fermentation with the addition of sulfate, and the resulting fermentation products were utilized in a pot experiment involving water spinach to assess the impact of anaerobically fermented straw return on soil Hg methylation and its bioaccumulation. Findings revealed that the addition of sulfate during straw fermentation markedly increased the fermentation degree of the products, and sulfate was converted into organic sulfur-containing ligands that can functionalize the fermentation residuals.
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