Wernicke's encephalopathy (WE) is a potentially reversible yet severe neurological manifestation caused by thiamine (vitamin B1) deficiency. It is commonly associated with heavy alcohol consumption. Other rare causes include severe and prolonged vomiting, starvation, and prolonged intravenous feeding. WE patients usually present with the triad of ocular signs, ataxia, and confusion. In non-alcoholic patients, the full classic triad develops in 10-16% of cases. Characteristic MRI findings and clinical response to thiamine confirm the diagnosis. In this report, we present a case of WE in the setting of transient gestational hyperthyroidism and hyperemesis gravidarum (HG).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515211PMC
http://dx.doi.org/10.7759/cureus.10012DOI Listing

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Wernicke's encephalopathy, Central Pontine Myelinolysis and Supraventricular Tachycardia in a Case of Hyperemesis Gravidarum.

Mymensingh Med J

January 2025

Dr Muhammad Rezeul Huq, Classified Specialist, Department of Neurology, Combined Military Hospital, Dhaka, Bangladesh; E-mail:

Wernicke's encephalopathy is a potentially lethal complication of thiamine deficiency which mainly occurs in chronic alcoholic patients. It may occur in other conditions like hyperemesis gravidarum too. Pregnancy may also be complicated with other neurological and cardiac complications.

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Introduction: Wernicke encephalopathy is a clinical diagnosis that requires a high degree of clinical suspicion to recognize. We report a case of a pregnant patient developing Wernicke encephalopathy in the setting of severe hyperemesis gravidarum.

Case Report: The patient was a 22-year-old female 13 weeks pregnant presenting to the emergency department (ED) with neurological deficits after several weeks of hyperemesis gravidarum requiring hospitalization.

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A pregnant woman was brought to the emergency department looking starved and neglected. She was diagnosed with sepsis and started on intravenous antibiotics. She was also disoriented and hypernatremic.

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Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad.

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