AI Article Synopsis

  • Ibrutinib is approved for treating chronic lymphocytic leukemia (CLL) but its effectiveness for multiple myeloma (MM) is still under research.
  • A case study showed a patient with CLL developed MM while being treated with ibrutinib.
  • This suggests that ibrutinib may not be effective in treating multiple myeloma.

Article Abstract

Ibrutinib is approved for chronic lymphocytic leukemia (CLL). However, its role in the treatment of multiple myeloma (MM) is not clear and is under investigation. We report a case of CLL that developed MM while on therapy with ibrutinib indicating that this drug may not be active against MM.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495781PMC
http://dx.doi.org/10.1002/ccr3.3019DOI Listing

Publication Analysis

Top Keywords

chronic lymphocytic
8
lymphocytic leukemia
8
therapy ibrutinib
8
emergence overt
4
overt myeloma
4
myeloma patient
4
patient chronic
4
leukemia ibrutinib
4
ibrutinib therapy
4
ibrutinib approved
4

Similar Publications

Atopic dermatitis is a chronic inflammatory skin disease associated with immune dysregulation, particularly overexpression of T helper 2 cytokines. Cytotoxic T lymphocyte-associated antigen 4 deficiency, a primary immune disorder, can exacerbate atopic dermatitis. Dupilumab, an IL-4 and IL-13 receptor antagonist, has demonstrated efficacy in controlling severe, recalcitrant atopic dermatitis by mitigating T helper 2-driven inflammation.

View Article and Find Full Text PDF

Background: Sepsis is a life-threatening condition arising from a dysregulated host response to infection leading to organ dysfunction. Traditional clinical signs are often unreliable for detecting sepsis, necessitating the exploration of more accurate biomarkers. Furthermore, currently, recommended screening scores perform poorly, necessitating more effective biomarkers to identify sepsis.

View Article and Find Full Text PDF

Chronic lymphocytic leukemia (CLL) can rarely transform into Waldenström macroglobulinemia (WM), posing diagnostic and therapeutic challenges. The diagnosis of WM requires bone marrow infiltration by lymphoplasmacytic cells and the presence of IgM gammopathy. Immunophenotypic markers include FMC7+, CD19+, CD20+, and CD138+.

View Article and Find Full Text PDF

Background: Microscopic colitis (MC) is a chronic inflammatory condition of the colon, primarily characterized by watery diarrhea, with normal or near-normal endoscopic findings. It encompasses two main subtypes: lymphocytic colitis and collagenous colitis.

Objective: This position paper from the Brazilian Federation of Gastroenterology aims to review current evidence on the diagnosis and management of MC in Brazil, emphasizing the need for standardization across the country's healthcare systems.

View Article and Find Full Text PDF

Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease characterized by increased skin sensitivity to environmental elements, mediated by CD4 T helper cells (Th2). Interleukin-33 (IL-33) plays a critical role in exacerbating symptoms in inflamed tissues. Conversely, vitamin D has been shown to induce antimicrobial peptides and suppress the inflammatory response.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!