AI Article Synopsis
- The case report details a 57-year-old woman with a history of multiple cancers including triple-negative breast cancer, thyroid carcinoma, and mucoepidermoid parotid carcinoma, linked to a BRCA1 mutation.
- She was diagnosed with her first breast cancer at 33, followed by subsequent tumors in the other breast and thyroid over the years.
- The findings suggest that BRCA1 mutations may also be associated with cancers outside the typical breast and ovarian types, such as salivary gland cancer.
Article Abstract
Objectives: To describe a patient with BRCA1 mutation, mucoepidermoid parotid, multiple breasts, and thyroid cancers.
Case Report: A women was diagnosed at 33-years-age with a triple-negative breast cancer (right breast), at 43-years-age with a triple-negative breast cancer in left breast and at 53-years-age with a primary papillary-thyroid carcinoma. At 55-years-age, she was diagnosed with a primary mucoepidermoid carcinoma in right parotid, and concomitantly, her right nipple was affected by Paget's disease and a recurrent carcinoma in right breast (HR + /HER2 = 3 +). At 57-years-age, after the recurrence of a triple-negative breast cancer (left breast), a geneticist evaluated the patient's family history, including one stomach, one non-smoking-related lung, and two smoking-related laryngeal cancers. Genetic testing revealed a BRCA1 mutation (Chr17:41:251.867). The patient's daughter (a non-cancer patient) tested negative for the mutation. Both remain under medical supervision.
Conclusions: We suggest that BRCA1 mutations are associated with non-breast and non-ovarian cancers such as salivary gland cancer.
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| http://dx.doi.org/10.1016/j.oooo.2020.08.017 | DOI Listing |
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