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Outcome of relapsed/refractory diffuse large B-cell lymphoma patients treated with polatuzumab vedotin-based therapy: real-life experience. | LitMetric

AI Article Synopsis

  • * Results showed a 61% overall response rate, with 40% achieving complete responses and a median overall survival of 8.3 months, indicating positive outcomes for this treatment.
  • * Factors like poor Eastern Cooperative Oncology Group performance status and primary refractory disease were linked to shorter survival and progression-free survival, highlighting their impact on treatment outcomes.

Article Abstract

The efficacy of polatuzumab vedotin in relapsed/refractory diffuse large B-cell lymphoma outside clinical study are undetermined. This retrospective study examined the efficacy and safety of polatuzumab vedotin administered in real life settings. Forty-seven patients, 31 with DLBCL and 16 with transformed lymphoma, treated with polatuzumab-based regimen in 14 Israeli centers between June 2018 and November 2019, were included. Median age was 66.1 years (60.4-78.8) and median number of prior lines was 3 (2-7). The overall response rate was 61% ( = 29), including 40% complete responses ( = 19) and 21% ( = 10) partial responses. The median overall survival and progression-free survival were 8.3 months and 5.6 months, respectively. An ECOG PS ≥2 predicted a decreased overall survival ( = 0.045). Primary refractory vs relapsed disease ( = 0.005) and transformed vs DLBCL ( = 0.039) were associated with shorter PFS ( = 0.027). Our data show that polatuzumab-based regimen is an effective and tolerable treatment in relapsed/refractory DLBCL.

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Source
http://dx.doi.org/10.1080/10428194.2020.1824069DOI Listing

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