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Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation.
Dermatol Online J
October 2023
Division of Dermatology, Tokushima Red Cross Hospital, Komatsushima, Tokushima, Japan.
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs.
View Article and Find Full Text PDFA case of anti-laminin γ1 (p200) pemphigoid developed after dipeptidyl peptidase-4 inhibitor administration.
J Dermatol
June 2024
Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
- A 73-year-old man with diabetes treated with sitagliptin developed widespread, itchy red skin lesions suspected to be a drug eruption due to the medication.
- Histopathological analysis revealed significant eosinophilic infiltration, leading to the discontinuation of sitagliptin and improvement with treatment, including prednisolone and phototherapy.
- Five months later, he experienced blistering lesions, and further tests indicated he had anti-laminin γ1 pemphigoid, a rare condition linked to the DPP-4 inhibitor, with some supporting autoimmune response findings.
Anti-laminin 332 antibody detection using biochip immunofluorescence microscopy in a real-life cohort of Italian patients with mucous membrane pemphigoid.
Eur J Dermatol
November 2022
Section of Dermatology, Department of health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Background: Mucous membrane pemphigoid (MMP) with anti-laminin 332 autoantibodies may be associated with malignancies, however, current serological assays have considerable limitations. At present, no commercial test for anti-laminin 332 antibodies is available, restricting the diagnosis to specialized laboratories worldwide. Biochip immunofluorescence microscopy has shown promising results in selected cohorts of laminin 332-MMP patients.
View Article and Find Full Text PDFPotential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid.
Front Immunol
February 2023
Department of Laboratory Medicine, Chronic Disease Research Center, Medical College, Dalian University, Dalian, China.
Article Synopsis
- Anti-p200 pemphigoid is a rare autoimmune skin disease first described in 1996, characterized by skin lesions and potential mucosal involvement, though the mechanisms of mucosal lesions are not well understood.* -
- A review of 32 studies identified 52 patients with mucosal lesions, revealing that 75% had oral lesions, 26.9% genital lesions, and 11.54% ocular lesions, with some patients also having other autoimmune diseases.* -
- The findings suggest that anti-p200 autoantibodies may play a unique role in causing mucosal lesions compared to other related autoimmune diseases, highlighting a distinct pattern, but further research is needed to clarify these mechanisms.*
The Intriguing Links between Psoriasis and Bullous Pemphigoid.
J Clin Med
December 2022
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
The coexistence of psoriasis with autoimmune bullous diseases (AIBDs), particularly bullous pemphigoid (BP), has been documented in case reports and series, as well as in epidemiological studies. The onset of psoriasis precedes that of BP in the majority of cases. Patients with concomitant BP and psoriasis are generally younger at the onset of BP and present with fewer erosions and blisters as compared with patients suffering from isolated BP.
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