AI Article Synopsis
- A nationwide study analyzed data from over 186,000 patients in South Korea to explore the link between retinal vein occlusion (RVO) and the risk of developing cancer.
- The findings showed that patients with RVO had a 29% higher risk of cancer compared to matched controls, with the incidence of cancer significantly higher in the RVO group (25.55 per 1000 person-years) than in the control group (18.62 per 1000 person-years).
- The greatest risk was seen with blood-related cancers, indicating a need for further research to understand the relationship and improve cancer screening recommendations for RVO patients.
Article Abstract
Aims: To investigate the association between incident retinal vein occlusion (RVO) and the subsequent development of cancer.
Methods: In this nationwide population-based retrospective study using 2002-2013 National Health Insurance Service database which covers the entire South Korean population, 186 701 incident RVO patients and their 1:1 propensity-score matched controls were included. We defined the fixed cohort from January 1st, 2004 to December 31st, 2013; the cohort included patients who suffered incident RVO after entering the cohort and their matched controls, and excluded patients having any cancer history before entering the cohort. The association of RVO and cancer was assessed by time-varying covariate Cox regression models; Model 1 included RVO as a time-varying covariate, Model 2 included Model 1 plus demographic information and Model 3 included Model 2 and comorbidities.
Results: RVO was associated with an increased risk of subsequent cancer (HR=1.29; 95% CI, 1.26-1.31 in Model 1), which was consistent in Models 2 and 3. The incidence rate of overall cancer during the study period was 25.55 (95% CI, 25.19-25.91) per 1000 person-years in the RVO group and 18.62 (95% CI, 18.46-18.79) per 1000 person-years in the control group. In the subgroup analysis, haematological malignancies showed the highest association with RVO (HR=1.65; 95% CI, 1.49-1.83).
Conclusion: Patients with RVO have an increased risk of subsequent cancer development even after adjusting for demographic factors and comorbidities. Further study is warranted to elucidate these associations to provide proper recommendations for RVO patients regarding the cancer screening.
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| http://dx.doi.org/10.1136/bjophthalmol-2020-316947 | DOI Listing |
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