AI Article Synopsis
- Spinal cord injuries (SCIs) are complex and challenging to treat, with a history of research dating back to 1911 when the first animal model was created.
- Many studies primarily concentrate on the molecular aspects of SCIs, but there is growing awareness that these injuries can also lead to mental and cognitive disorders.
- There is currently no agreement on the best animal model for researching the brain changes that occur as a result of spinal cord injuries.
Article Abstract
Spinal cord injuries (SCIs) are difficult to treat. The first animal SCI model (featuring the dropping of a weight) was established by Allen in 1911, and other animal models have been developed since then. Most animal studies have focused only on the molecular features of SCIs, which remain disputed. Recently, it has become clear that SCI may trigger mental and cognitive disorders, however, and brain changes secondary to SCI are under investigation. No consensus on an optimal animal model for cerebral research has emerged. We discuss the appropriate SCI models for studying secondary brain changes.
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| http://dx.doi.org/10.1016/j.wneu.2020.09.103 | DOI Listing |
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