AI Article Synopsis
- The study investigates cardiac-induced brain tissue pulsations (BTPs) and aims to establish reference data from healthy individuals for future clinical applications.
- BTPs were measured in 107 healthy participants, analyzing factors like age, sex, heart rate, and blood pressure, revealing significant variations in pulsation amplitudes linked to pulse pressure.
- A subset of participants also underwent MRI scans to correlate ultrasound measurements with brain anatomy, highlighting regional differences in BTP based on depth and probe placement.
Article Abstract
It is well known that the brain pulses with each cardiac cycle, but interest in measuring cardiac-induced brain tissue pulsations (BTPs) is relatively recent. This study was aimed at generating BTP reference data from healthy patients for future clinical comparisons and modelling. BTPs were measured through the forehead and temporal positions as a function of age, sex, heart rate, mean arterial pressure and pulse pressure. A multivariate regression model was developed based on transcranial tissue Doppler BTP measurements from 107 healthy adults (56 male) aged from 20-81 y. A subset of 5 participants (aged 20-49 y) underwent a brain magnetic resonance imaging scan to relate the position of the ultrasound beam to anatomy. BTP amplitudes were found to vary widely between patients (from ∼4 to ∼150 µm) and were strongly associated with pulse pressure. Comparison with magnetic resonance images confirmed regional variations in BTP with depth and probe position.
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| http://dx.doi.org/10.1016/j.ultrasmedbio.2020.08.020 | DOI Listing |
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