Myocardial perfusion assessment with contrast echocardiography has been studied for more than 25 years. It is a feasible and safe technique. Rather it has an additional value in pharmacologic stress test remains unclear. However, with adequate settings (using both low and very low mechanical index), perfusion analysis can be very useful for the diagnosis of apical thrombus or tumor, viability assessment, and acute coronary syndrome with non-informative ECG.
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