Evaluation of Bruch's membrane opening-minimum rim width and retinal nerve fiber layer thickness in adults with anisometropic amblyopia.

Purpose: To investigate the relationship between Bruch's membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT) in adult patients anisometropic amblyopia using spectral domain optical coherence tomography (SD-OCT).

Materials And Methods: In this cross-sectional, observational study, 43 anisometropic eyes with corresponding fellow eyes. BMO-MRW (shortest distance from BMO to the internal limiting membrane) and peripapillary RNFLT were obtained with Spectral Domain Optic Coherence Topography (SD-OCT). Global and six sectors values according to the legacy distribution of the SD-OCT (nasal [N], nasal superior [NS], temporal superior [TS], temporal [T], temporal inferior [TI], and nasal inferior [NI]) for both RNFLT and BMO-MRW were evaluated.

Results: Mean RNFLT and BMO-MRW measurements comparison showed no significance between anisometropia and fellow eyes. In correlation analyses ; although all sectors showed significant positive correlations; the global, TS and NI BMO-MRW sectors were significantly correlated with their corresponding RNFLT within both anisometropia and fellow eyes. In subgroup caparison analyses RNFLT and BMO-MRW showed no differences between amblyopia and fellow eyes. On subgroups correlation analyses, there were not a consistent correlation sectors between RNFLT and BMO-MRW.

Conclusions: In the analysis of the BMO-MRW and RNFLT measurements obtained by SD-OCT in adult anisometropic amblyopia patients, both parameters were evaluated not significant on showing structural changes. In correlation analysis within amblyopic and fellow eye groups, while there was positive correlation on all sectors, statistically significant relationships were detected in global, NI, TS sectors for both BMO-MRW and RNFLT measurements.