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Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters. | LitMetric

Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters.

FEBS Lett

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.

Published: March 2021

AI Article Synopsis

  • Low oxygen levels (hypoxia) play a crucial role in how the placenta functions and manages chemicals.
  • A study comparing two human placental models (BeWo cells and term placental explants) revealed that low oxygen affects various transport proteins differently, with some being increased while others were decreased.
  • Additionally, hypoxia led to a drop in certain transcription factors, indicating that oxygen concentration influences transporter expression in the placenta in unique ways.

Article Abstract

Low oxygen concentration, or hypoxia, is an important physiological regulator of placental function including chemical disposition. Here, we compared the ability of low oxygen tension to alter the expression of solute carriers (SLC) and ABC transporters in two human placental models, namely BeWo cells and term placental explants. We found that exposure to low oxygen concentration differentially regulates transporter expression in BeWo cells, including downregulation of ENT1, OATP4A1, OCTN2, BCRP, and MRP2/3/5, and upregulation of CNT1, OAT4, OATP2B1, SERT, SOAT, and MRP1. Similar upregulation of MRP1 and downregulation of MRP5 and BCRP were observed in explants, whereas uptake transporters were decreased or unchanged. Furthermore, a screening of transcriptional regulators of transporters revealed that hypoxia leads to a decrease in the mRNA levels of aryl hydrocarbon receptor, nuclear factor erythroid 2-related factor 2, and retinoid x receptor alpha in both human placental models. These data suggest that transporter expression is differentially regulated by oxygen concentration across experimental human placental models.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987846PMC
http://dx.doi.org/10.1002/1873-3468.13937DOI Listing

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