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DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer's disease.
Sci Rep
January 2025
Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
Alzheimer's Disease (AD) significantly aggravates human dignity and quality of life. While newly approved amyloid immunotherapy has been reported, effective AD drugs remain to be identified. Here, we propose a novel AI-driven drug-repurposing method, DeepDrug, to identify a lead combination of approved drugs to treat AD patients.
View Article and Find Full Text PDFExperiences of healthcare professionals returning to work post breast cancer diagnosis in China: A descriptive qualitative study.
Sci Rep
January 2025
Nursing Department, Huzhou Maternity & Child Health Care Hospital, Huzhou, 313000, China.
Breast cancer survivors face employment challenges. How to promote BC's return to work is important for improving their quality of life and promoting recovery. Numerous studies have reported that BC survivors encounter employment challenges due to cognitive limitations, alongside factors.
View Article and Find Full Text PDFBlack/White disparities in low birth weight across maternal trajectories of social mobility in South Carolina.
Soc Sci Med
January 2025
Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA.
Persistent racial disparities in low birth weight (LBW) in the United States may be better understood through the adoption of a life course perspective that considers differential exposure and vulnerability of Black and White women to socioeconomic position across generations. Using a multigenerational dataset of singleton birth certificates from South Carolina from 1989 to 2020 linked along the maternal line, we constructed intergenerational social mobility trajectories of grandmaternal and maternal education and compared unadjusted and adjusted associations between trajectories and LBW among Black and White women. We found that White women were more likely to be upwardly mobile, and Black women to be downwardly mobile.
View Article and Find Full Text PDFDifferential protective effects of Family Income-to-Poverty-Ratio on electronic cigarette, depression, and obesity of Black and White Americans.
AIMS Public Health
December 2024
Departments of Urban Public Health, Internal Medicine, and Family Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
Background: The Family Income-to-Poverty-Ratio (FIPR) is a recognized indicator of socioeconomic status, and influences a wide range of health and behavioral outcomes. Yet, marginalized and racialized groups, particularly Black individuals, may not reap comparable health benefits from their socioeconomic advancements as their non-Hispanic, White counterparts. This discrepancy is indicative of a phenomenon known as the minorities' diminished returns.
View Article and Find Full Text PDFEvolving the job demands-resources framework to JD-R 3.0: The impact of after-hours connectivity and organizational support on employee psychological distress.
Acta Psychol (Amst)
January 2025
Department of Psychology, Renmin University of China, Beijing, China.
This study extends the Job Demands-Resources (JD-R) framework by proposing JD-R 3.0, which explores the dynamic and nonlinear relationships among Work Connectivity Behavior After-Hours (WCBA), Perceived Organizational Support (POS), and employee outcomes, with a specific focus on psychological contract violation (PCV) and psychological distress. Data were collected from 625 employees in a large financial organization in China across two waves, and polynomial regression and response surface analysis were used for hypothesis testing.
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