is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, in preventing joint infections. Iclaprim (2.5-80 mg kg ) administered as a single dose via the tail vein reduced the incidence of septic arthritis and mortality in an experimental murine model of septic arthritis.
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