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Emergence of plasmid-borne gene in : first report from India. | LitMetric

Emergence of plasmid-borne gene in : first report from India.

Access Microbiol

Antibiotic Resistance and Phage Therapy Laboratory, Department of Biomedical Sciences, School of Bioscience and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India.

Published: May 2019

AI Article Synopsis

  • Wastewater is a growing habitat for multi-drug-resistant bacteria, prompting research into carbapenem-resistant bacteria in sewage samples.* -
  • The study analyzed 19 sewage samples, successfully isolating 100 carbapenem-resistant non-lactose-fermenting Gram-negative bacteria using specific culture techniques.* -
  • One isolate was identified to carry a plasmid-borne resistance gene (OXA-181), marking the first report of this concerning opportunistic pathogen in such a context.*

Article Abstract

Wastewater has become a potential habitat for multi-drug-resistant bacteria. The present study aims to screen for the presence of carbapenem-resistant bacteria in sewage water samples collected from hospital and non-hospital sources. From a total of 19 sewage water samples collected, 100 carbapenem-resistant non-lactose-fermenting Gram-negative bacteria (CR-NF-GNB) were isolated using MacConkey agar cultured with 8 mg l of meropenem. On screening for beta-lactamase resistance genes ( , , , and ), one isolate, , was found to carry the plasmid-borne gene. To the best of our knowledge, we provide the first report of the rare and emerging opportunistic pathogen encoding the OXA-181 gene in its plasmid.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471779PMC
http://dx.doi.org/10.1099/acmi.0.000024DOI Listing

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