AI Article Synopsis
- The study examines the link between alcohol preference in rats and metabolic disorders, using specially bred rat lines: WHP (high-preferring) and WLP (low-preferring).
- Blood samples from alcohol-naïve male offspring of these rat lines and wild Wistar rats showed significant differences in metabolic biomarkers, including triglycerides and cholesterol levels.
- Results indicate that even without alcohol exposure, offspring of WHP rats had altered metabolic markers, hinting that parental alcohol use may negatively affect the offspring's risk of metabolic diseases.
Article Abstract
Alcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present study was to compare the levels of selected laboratory biomarkers of metabolic disorders in blood samples from naïve offspring of Warsaw alcohol high-preferring (WHP), Warsaw alcohol low-preferring (WLP), and wild Wistar rats. Blood samples were collected from 3-month old (300-350 g) alcohol-naïve, male offspring of WHP ( = 8) and WLP rats ( = 8), as well as alcohol-naïve, male, wild Wistar rats. Markers of metabolic, hepatic, and pancreatic disorders were analysed (levels of homocysteine, glucose, total cholesterol, triglycerides and -glutamyl transferase (GGT), aspartate (AST), alanine aminotransferase (ALT), and amylase serum activities). Alcohol-naïve offspring of WHP, WLP, and wild Wistar rats differed significantly in the levels of triglycerides, total cholesterol, homocysteine, as well as in the activity of GGT, ALT, AST, and amylase enzymes. Most markers in the alcohol-naïve offspring of WHP rats were altered even thought they were never exposed to alcohol pre- or postnatally. This may suggest that parental alcohol abuse can have a detrimental influence on offspring vulnerability to metabolic disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489241 | PMC |
| http://dx.doi.org/10.7717/peerj.9886 | DOI Listing |
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