Cyclic Peptide [RW] in Improving the Ability of First-Line Antibiotics to Inhibit Inside Human Granulomas.

Tuberculosis (TB) is currently one of the leading causes of global mortality. Medical non-compliance due to the length of the treatment and antibiotic side effects has led to the emergence of multidrug-resistant (MDR) strains of () that are difficult to treat. A current therapeutic strategy attempting to circumvent this issue aims to enhance drug delivery to reduce the duration of the antibiotic regimen or dosage of first-line antibiotics. One such agent that may help is cyclic peptide [RW], as it has been shown to have antibacterial properties (in combination with tetracycline) against methicillin-resistant (MRSA) in the past. The objective of this study is to test cyclic peptide [RW] both alone and in combination with current first-line antibiotics (either isoniazid or pyrazinamide) to study the effects of inhibition of inside human granulomas. Results from our studies indicate that [RW] is efficacious in controlling infection in the granulomas and has enhanced inhibitory effects in the presence of first-line antibiotics.