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Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ peptide ameliorates neurological deficits after ischemic stroke.
Int Immunopharmacol
April 2024
Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address:
Background: Fibrin(ogen) deposition in the central nervous system (CNS) contributes to neuropathological injury; however, its role in ischemic stroke is unknown. In this study, we identified fibrinogen as a novel proinflammatory regulator of post-stroke neuroinflammation and revealed the neuro-protection effect of fibrin-derived γpeptide in stroke.
Methods: Fibrinogen depletion and fibrinogen-derived γpeptide treatment were performed 2 h after establishing a permanent middle cerebral artery occlusion (pMCAO) model.
Unlocking endothelial barrier restoration: FX06 in systemic capillary leak syndrome and beyond.
Biomed Pharmacother
February 2024
Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Increased vascular permeability is a prevalent feature in a wide spectrum of clinical conditions, but no effective treatments to restore the endothelial barrier are available. Idiopathic systemic capillary leak syndrome (ISCLS) is a life-threatening Paroxysmal Permeability Disorder characterized by abrupt, massive plasma extravasation. This condition serves as a robust model for investigating therapeutic approaches targeting interendothelial junctions.
View Article and Find Full Text PDFBackground: In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management. However, heterogeneity might be partially artificial because of the use of heterogeneous methods for ACPA detection. In recent work instead, we found that ACPA were mainly directed towards a single fibrin-derived peptide, β60-74BiotNt, but a comparative analysis with the presence of other ACPA specificities is still lacking.
View Article and Find Full Text PDFSynthetic Fibrin-Derived Bβ Peptide Delays Thrombus Resolution in a Mouse Model.
Arterioscler Thromb Vasc Biol
July 2021
Division of Cardiology, Department of Internal Medicine II (S.C., S.S., I.M.L.), Medical University of Vienna, Austria.
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View Article and Find Full Text PDFLassa hemorrhagic shock syndrome-on-a-chip.
Biotechnol Bioeng
March 2021
Medical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Lack of experimental human models hinders research on Lassa hemorrhagic fever and the development of treatment strategies. Here, we report the first chip-based model for Lassa hemorrhagic syndrome. The chip features a microvessel interfacing collagen network as a simple mimic for extracellular matrix, allowing for quantitative and real-time vascular integrity assessment.
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