Objective: To assess changes in plasma exosome levels and protein content in mice after long-term exercise.
Methods: We subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived exosomes. Exosomal proteins were identified using mass spectrometry.
Results: Extracellular bodies were successfully isolated from mouse blood. Protein levels were altered in blood-derived exosomes after chronic treadmill exercise. Levels of the secretagogue secretogranin 2 were markedly elevated in exercise-induced exosomes.
Conclusion: Our data suggest that levels of secretogranin 2 were increased in mouse exosomes following chronic treadmill exercise. We conclude that exercise increases exocrine secretion of secretogranin 2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522842 | PMC |
| http://dx.doi.org/10.1177/0300060520957541 | DOI Listing |
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