AI Article Synopsis
- Proteasome inhibitors are important for research and treatment, and the study focuses on specific platinum complexes with anthracenyl and heterocyclic rings.
- Lineweaver-Burk analysis showed that the structure of the heterocycle influences how these platinum complexes bind, with different binding modes leading to either competitive or non-competitive inhibition types.
- The research highlights that the anthracenyl component is key for strong proteasome inhibition, whereas complexes with naphthyl or phenyl rings display weaker activity.
Article Abstract
Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure-activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver-Burk analysis revealed that the chemical structure of heterocycles affects the binding mode of platinum complexes. Platinum complexes with anthracenyl ring and pyridine showed competitive inhibition, although platinum complexes with anthracenyl ring and phenanthroline showed non-competitive inhibition. The structure-activity relationships demonstrated that anthracenyl moiety plays a crucial role in proteasome-inhibitory activity. The platinum complexes with naphthyl or phenyl rings exhibited lower inhibitory activities than the platinum complex with anthracenyl ring. The reactivity with N-acetylcysteine varied according to the chemical structure of complexes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481701 | PMC |
| http://dx.doi.org/10.1098/rsos.200545 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-Efficiency, Long-Lifetime and Color-Tunable Hybrid WOLEDs Using a Platinum Complex with Voltage-Dependent Monomer and Aggregate Emission.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Synthetic Chemistry, Department of Chemistry, HKU-CAS Joint Laboratory on New Materials, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 999077, P. R. China.
Color-tunable white organic light-emitting diodes (CT-WOLEDs) have attracted widespread attention given their large color variation to meet the different daily scenarios from the perspective of circadian rhythm. However, most reported CT-WOLEDs, especially the tri-color devices, exhibit poor performances and sophisticated structures. Here, a simple structure tri-color CT-WOLED is demonstrated that simultaneously exhibits high efficiency, ultralong operation lifetime, and wide color-tunable range for dynamic sunlight emulation.
View Article and Find Full Text PDFRecent advances in ruthenium（III） complex-loaded nanomaterial for enhanced cancer therapy efficacy.
Drug Dev Ind Pharm
January 2025
Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China.
Objective: Amid the escalating global cancer incidence, the development of effective and safe anticancer drugs is a critical priority in medical research. Addressing the clinical shortcomings of ruthenium-based anticancer drugs are currently a prominent focus of research.
Significance And Methods: Since the pioneering work with platinum derivatives, significant progress has been made in the fundamental studies of metal complexes for the treatment of a wide range of cancers, and there has been a growing interest in their properties and biomedical applications.
Earth-abundant transition metal complexes in light-emitting electrochemical cells: successes, challenges and perspectives.
Dalton Trans
January 2025
Normandy University, ENSICAEN, UNICAEN, CNRS, LCMT, 6 Bd du Maréchal Juin, 14050 Caen, France.
Light-emitting electrochemical cells (LECs) are an attractive technology in the field of solid state light devices (SSLDs) as their simple architectures allow the preparation of cost-effective lighting devices. Consequently, low-cost and sustainable emitters are highly desirable. Transition metal complexes are attractive in this field as they have been proved to possess compatible optoelectronic properties.
View Article and Find Full Text PDFAn open-shell Ir(II)/Ir(IV) redox couple outperforms an Ir(I)/Ir(III) pair in olefin isomerization.
Nat Chem
January 2025
Instituto de Investigaciones Químicas, Consejo Superior de Investigaciones Científicas and Universidad de Sevilla, Sevilla, Spain.
Open-shell systems based on first-row transition metals and their involvement in various catalytic processes are well explored. By comparison, mononuclear open-shell complexes of precious transition metals remain underdeveloped. This is particularly true for Ir complexes, as there is very limited information available regarding their application in catalysis.
View Article and Find Full Text PDFPhotoinduced formation of a platina-α-lactone - a carbon dioxide complex of platinum. Insights from femtosecond mid-infrared spectroscopy.
Phys Chem Chem Phys
January 2025
Abteilung für Molekulare Physikalische Chemie, Clausius-Institut für Physikalische und Theoretische Chemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Wegelerstraße 12, 53115 Bonn, Germany.
The binding of carbon dioxide to a transition metal is a complex phenomenon that involves a major redistribution of electron density between the metal center and the triatomic ligand. The chemical reduction of the ligand reveals itself unambiguously by an angular distortion of the CO-molecule as a result of the occupation of an anti-bonding π-orbital and a shift of its antisymmetric stretching vibration, ν, to lower wavenumbers. Here, we generate a carbon dioxide complex of the heavier group-10 metal, platinum, by ultrafast electronic excitation and cleavage of CO from the photolabile oxalate precursor, oxaliplatin, and monitored the ensuing primary dynamics with ultrafast mid-infrared spectroscopy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!