We often come across difficult to treat infections-even after administering appropriate antibiotics according to the minimal inhibitory concentration of the causative bacteria. Antibiotic tolerance has recently started to garner attention as a crucial mechanism of refractory infections. However, few studies have reported the correlation between clinical outcomes and antibiotic tolerance. This study aims to clarify the effect of antibiotic tolerance on clinical outcomes of respiratory tract infection caused by (). We examined a total of 63 strains isolated from sputum samples of different patients and conducted a retrospective survey with the medical records of 37 patients with imipenem-sensitive infections. Among them, we selected 15 patients with respiratory infections, and they were divided into high-tolerance minimal bactericidal concentration for adherent bacteria (MBC)/minimal inhibitory concentration for adherent bacteria (MIC) ≥ 32 ( = 9) group and low-tolerance MBC/MIC ≤ 16 ( = 6) group for further investigations. The findings indicated that the high-tolerance group consisted of many cases requiring hospitalization. Chest computed tomography findings showed that the disease was more extensive in the high-tolerance group compared to the low-tolerance group. Regarding the bacterial phenotypic characterization, the high-tolerance group significantly upregulated the production of the virulence factors compared to the low-tolerance group. Our study provided evidence that carbapenem tolerance level is a potent prognostic marker of infections, and carbapenem tolerance could be a potential target for new antimicrobial agents to inhibit the progression of persistent infections.
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http://dx.doi.org/10.3390/antibiotics9090626 | DOI Listing |
Front Cell Infect Microbiol
December 2024
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
This study explores the potential of indigenous non- yeasts isolated from L. grape skins to improve the quality of regional wines by enhancing their physicochemical and sensory characteristics. Five promising yeast strains were identified at different stages of fermentation: (J1Y-T1), (Y5P-T5), (JF3-T1N), (Y8P-T8), and (WMP4-T4).
View Article and Find Full Text PDFTuberculosis (Edinb)
December 2024
Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, TN, 38105, USA. Electronic address:
Tetracycline analogs from the minocycline family have recently shown promise for the treatment of non-tuberculous mycobacterial infections. However, current tetracycline and minocycline therapeutics can be limited by tolerability, stability, or inactivation by TetX. In this study, a series of novel 9-heteroaryl substituted minocycline analogs were designed and synthesized, which resulted in analogs with good in vitro activity against Mycobacterium tuberculosis and Mycobacterium abscessus, stability in water for more than 7 days, avoidance of TetX inactivation in M.
View Article and Find Full Text PDFCan J Microbiol
December 2024
The First Affiliated Hospital of Wenzhou Medical University, Department of Clinical Laboratory, Wenzhou, Zhejiang, China;
The objective of this study was to compare chlorhexidine digluconate and other antibiotics susceptibility of 4 species in Acinetobacter baumannii complex, and further investigate the CHG tolerance mechanisms and molecular epidemic characteristics. Of 889 A. baumannii complex isolates, A.
View Article and Find Full Text PDFmBio
December 2024
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Unlabelled: Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division. TA systems have also been implicated in bacterial persistence and antibiotic tolerance, which can be precursors of antibiotic resistance. Here, we identified a clinical isolate of (CS14) with a remarkably stable pINV virulence plasmid; pINV is usually frequently lost from , but plasmid loss was not detected from CS14.
View Article and Find Full Text PDFBioresour Technol
December 2024
CAS Key Laboratory of Quantitative Engineering Biology, Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, China. Electronic address:
Improper treatment of livestock and poultry wastewater (LPWW) rich in ammonium nitrogen (NH-N) and antibiotics leads to eutrophication, and contributes to the risk of creating drug-resistant pathogens. The design-build-test-learn strategy was used to engineer a continuous process using Chlorella vulgaris to remove NH-N and antibiotics. The optimized system removed NH-N at a rate of 306 mg/L/d, degraded 99 % of lincomycin, and reduced the hydraulic retention time to 4 days.
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