The tumor microenvironment plays a crucial role in driving the behavior and the aggressiveness of neoplastic cells [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555678 | PMC |
| http://dx.doi.org/10.3390/ijms21186915 | DOI Listing |
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Article Synopsis
- Normal tissues adjacent to breast tumors (NATs) may contain early signs of breast cancer development due to a phenomenon called field cancerization.
- A study using advanced genomic techniques on samples from 43 breast cancer patients in Hong Kong revealed that NATs often had single-nucleotide variants (SNVs) in driver genes also found in tumor samples, but rarely had large-scale genomic changes.
- The researchers identified different evolutionary patterns among NAT and tumor pairs, indicating distinct genomic characteristics and the influence of the tumor microenvironment on cancer development.
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