Background: In the pathogenesis of intermittent allergic rhinitis (IAR), the inflammatory reaction is of importance. CD48, belonging to the CD2 family, participates in mast cell-stimulating cross-talk, facilitates the formation of the mast cell/eosinophil effector unit, and is expressed by eosinophils.
Objectives: To assess the serum level of soluble form of CD48 (sCD48) in patients with IAR during and out of the pollen season and correlate with the disease severity and with eosinophil-related parameters.
Materials And Methods: Sixty-three patients (female: 79%; mean age: 30.58) were included to the study. Forty-five patients were assessed during the pollen season and other 42 patients during out of the pollen season. Twenty-four patients (female: 37.50%; mean age: 27.90) were evaluated twice, during the pollen season and out of the pollen season. sCD48, ECP, eotaxin-1/CCL11 serum levels together with complete blood count, and fractional exhaled nitric oxide bronchial and nasal fraction (FeNO) were performed. The severity of symptoms was assessed using the Total Nasal Symptom Score (TNSS), and neutrophil-to-lymphocyte (NLR) and eosinophil-to-lymphocyte (ELR) ratios were calculated.
Results: sCD48 serum level, FeNO nasal and bronchial fractions, and TNSS were significantly higher in the IAR group in the pollen season compared with out of the pollen season. Differences in ECP, eotaxin-1/CCL11 serum levels, and NLR and ELR were not significant between season and out of the season. No correlations were found between sCD48 and eosinophil-related parameters.
Conclusions: sCD48 may be a biomarker to the exacerbation phase in patients with IAR. One can assume that CD48 participates in the pathogenesis of IAR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000510166 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Climate Change and Allergens: Current and Future Impacts.
J Allergy Clin Immunol Pract
March 2025
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. Electronic address:
Climate change will continue to impact allergic diseases in direct and indirect ways. Rising global temperatures are contributing to increased duration of pollen seasons, altered aeroallergen production and potency of allergens, and changes in the geographic distribution of allergenic plants that drive increased human exposure to aeroallergens and increased allergic disease morbidity. Climate change is inextricably linked with air pollution, the latter of which was shown to act as an adjuvant for allergic inflammatory processes promoting allergic sensitization.
View Article and Find Full Text PDFClimate change may hinder species' ability to evolutionarily adapt to environmental shifts. Assisted gene flow, introducing adaptive alleles into target populations, could be a viable solution for keystone species. Our study aimed to evaluate the benefits and limitations of assisted gene flow in enhancing the evolutionary potential of L.
View Article and Find Full Text PDFComparative Evaluation of an Allergen Exposure Chamber and Nasal Allergen Challenge Versus In-Field Symptom Assessment in Patients With Allergic Rhinitis Triggered by Timothy Grass Pollen.
Allergy
March 2025
Department of Clinical Immunology, Faculty of Medicine of Wroclaw Medical University, Wroclaw, Poland.
Background: An allergen exposure chamber (AEC) is a specialized medical facility designed to expose individuals to allergens at precise and consistent concentrations within a controlled environment. This study aimed to correlate the assessment of clinical endpoints in patients with allergic rhinitis sensitized to timothy grass pollen (Phleum pratense) by comparing three different methods: AEC, nasal allergen challenge (NAC), and symptoms during natural exposure during the grass pollen season.
Methods: Fifteen allergic subjects and twelve healthy controls were evaluated in the ALLEC AEC; allergic symptoms were measured by subjective and objective methods, including total nasal symptom score (TNSS), acoustic rhinometry (AcR), peak nasal inspiratory flow (PNIF), and nasal discharge amount.
Long-term impact of a birch/alder/hazel or birch-only liquid sublingual immunotherapy on birch-family pollen respiratory allergy: A real-world study.
Allergol Int
March 2025
Respiratory Pharmacology Research Unit, VIM Suresnes, UMR_0892, University Paris-Saclay, Suresnes, France; Department of Airway Diseases, Hospital Foch, Suresnes, France.
Background: Patients with allergic rhinitis (AR) and/or mild or moderate asthma derived from birch-family pollen allergy can be treated with liquid sublingual immunotherapy (SLIT-liquid). This study evaluated the impact of two SLIT extracts on AR and asthma progression or onset in these patients.
Methods: This was a sub-analysis of a retrospective, longitudinal comparative cohort study that used a German prescription database.
Survey Health Data on Allergic Rhinitis (AR) and Asthmatic Symptoms and Blood Samples (IgE Sensitizations) in Preschool Children: An Observational Study.
Pediatr Pulmonol
March 2025
Department of Occupational and Environmental Health/Epidemiology, Bavarian Health and Food Safety Authority, Munich, Germany.
Background: Aim of the study was to investigate the association of IgE sensitizations in serum and self-reported allergic rhinitis (AR) and asthmatic symptoms.
Methods: Between 2015 and 2018, parents of 1190 children in Günzburg, Germany participated in the study by completing a questionnaire. Settings were the Health-Monitoring-Units (HMU) during the obligatory school entry examinations and a medical examination for all German children at the age of 60-64 months (U9).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!