How LINC complexes mediate nuclear mechanotransduction remains unclear. In this issue, Déjardin, Carollo, et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201908036) show that the LINC complex protein nesprin-2G is a mechanosensor of epithelial-mesenchymal transitions (EMTs), recruiting α-catenin to the nucleus to attenuate Wnt/β-catenin signaling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659724 | PMC |
| http://dx.doi.org/10.1083/jcb.202009042 | DOI Listing |
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