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Do specific myelin autoantibodies and increased cerebral dopamine neurotrophic factor in the context of inflammation predict the diagnosis of attention deficit hyperactivity disorder in medication-free children?
Brain Behav Immun
February 2025
Department of Radiology, Konya City Hospital, Karatay-Konya 42020, Turkey. Electronic address:
Article Synopsis
- The study examined the serum levels of various proteins related to myelin and inflammation in children with ADHD compared to healthy controls, focusing on their connection to clinical severity and irritability.
- Researchers included 141 ADHD children aged 8-14 and 135 typical controls, measuring protein levels using specific assays and assessing behaviors with standardized scales.
- Results indicated significantly higher levels of certain proteins (MAG, CDNF, hs-CRP, reelin, cerebellin) in ADHD children, alongside increased irritability, and noted significant correlations between some protein levels and clinical symptoms of ADHD and related disorders.
Intravenous Reelin rescues despair-like behavior, Reelin cells in the dentate sub-granular zone, and spleen atrophy in the cyclic corticosterone model of recurring depressive episodes.
Front Pharmacol
February 2024
Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
Novel antidepressants are predominantly evaluated preclinically in rodent models of chronic stress in which animals experience a single prolonged exposure to chronic stress prior to treatment. Rodent models of a single episode of chronic stress translate poorly to human depressive disorders, which are commonly marked by recurring depressive episodes. Intravenous administration of Reelin has previously been shown to resolve immobility in the forced swim test of rats exposed to a single prolonged exposure to chronic stress.
View Article and Find Full Text PDFWhole-exome sequencing has revealed novel genetic characteristics in intracranial germ cell tumours in the Chinese.
Histopathology
June 2024
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Aims: Intracranial germ cell tumour (IGCT) is a type of rare central nervous system tumour that mainly occurs in children and adolescents, with great variation in its incidence rate and molecular characteristics in patients from different populations. The genetic alterations of IGCT in the Chinese population are still unknown.
Methods And Results: In this study, 47 patients were enrolled and their tumour specimens were analysed by whole-exome sequencing (WES).
Macular Edema in Central Retinal Vein Occlusion Correlates With Aqueous Fibrinogen Alpha Chain.
Invest Ophthalmol Vis Sci
February 2023
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Purpose: The global protein profile of the aqueous humor has been found to correlate with the severity of retinal vascular disease. Studying the aqueous humor in central retinal vein occlusion (CRVO) with proteomic techniques may bring insights to the molecular mechanisms underlying the condition.
Methods: Aqueous humor samples from treatment naïve patients with CRVO complicated by macular edema (n = 28) and age-matched controls (n = 20) were analyzed by label-free quantification liquid chromatography - tandem mass spectrometry.
Using publicly available datasets to identify population-based transcriptomic landscape contributing to the aggressiveness of breast cancer in young women.
Front Genet
January 2023
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Healthcare City, Dubai, United Arab Emirates.
Although the risk of breast cancer increases with advancing age, some regions have larger number of young breast cancer patients (≤45 years-old), such as the Middle East, Eastern Asia, and North Africa, with more aggressive and poorly differentiated tumors. We aimed to conduct an analysis in an attempt to understand the aggressive nature of early-onset breast cancer, and to identify potential drivers of early-onset breast cancer using gene expression profiling datasets in a population-dependent manner. Functional genomics experiments data were acquired from cBioPortal database for cancer genomics, followed by the stratification of patients based on the age at representation of breast cancer and race.
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