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Disruption of circadian rhythm as a potential pathogenesis of nocturia.
Nat Rev Urol
November 2024
Department of Biomedical Engineering, Lerner Research Institute and Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Increasing evidence suggested the multifactorial nature of nocturia, but the true pathogenesis of this condition still remains to be elucidated. Contemporary clinical medications are mostly symptom based, aimed at either reducing nocturnal urine volume or targeting autonomic receptors within the bladder to facilitate urine storage. The day-night switch of the micturition pattern is controlled by circadian clocks located both in the central nervous system and in the peripheral organs.
View Article and Find Full Text PDF[Chronopharmacology : The right timing can be crucial].
Urologie
August 2022
Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Universitäres Cancer Center Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Background: Chronopharmacology takes into account, among other things, the circadian rhythm, a recurring, daily rhythm of biological functions that is significantly influenced by the day-night rhythm. Daily rhythm, diseases, and therapies influence each other: the circadian rhythm, among other factors, could influence the effect of pharmacological and nonpharmacological therapies, especially in urological oncology.
Aim: This article focuses on the question of the optimal time for therapeutic interventions and considers relevant basics of chronobiological principles depending on possible biomarkers that could be targets of a future therapeutic approach.
Introduction: Currently, chronic recurrent cystitis is one of the most important problems in urology. Considering the role of immune status disorders in the pathogenesis of inflammatory diseases, the use of immunocorrective drugs as part of the complex therapy is of particular relevance.
Aim: to study the efficiency of therapy for chronic recurrent bacterial cystitis in combination with immunomodulators (Galavit).
[Chronobiological features of different regimens of testosterone gel therapy in men with androgen deficiency].
Urologiia
October 2018
Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.
Introduction: Androgens play a key role in the male development. All the physiological processes in the body, including the production of testosterone, have their chronobiological features. Aging is accompanied by a disruption in the regulation of chronobiological processes.
View Article and Find Full Text PDF[Chronobiological approach to managing an exacerbation of chronic recurrent bacterial cystite].
Urologiia
June 2017
Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.
Aim: To investigate the effects of complex therapy with and without phototherapy for an exacerbation of chronic recurrent bacterial cystitis in women at the peaks of chronobiological activity.
Materials And Methods: The study comprised 60 patients (mean age 30.1+/-5.
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