AI Article Synopsis
- The study focused on the effects of the PK23 hybrid peptide, which combines opioid and neurotensin properties, administered to male rats to assess its pain-relieving abilities.
- The peptide demonstrated a strong pain-relieving effect in response to heat, showing better side effects compared to morphine, such as less scratching and slower tolerance development.
- Despite some adverse reactions at higher doses, the findings suggest that hybrid compounds like PK23 could be valuable in future pain management therapies.
Article Abstract
The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose of 10 nmol/rat produced a potent pain-relieving effect, especially after its intrathecal administration. Compared with intrathecal morphine, this novel compound was found to possess a favourable side effect profile characterized by a reduced scratch reflex, delayed development of analgesic tolerance or an absence of motor impairments when given in the same manner, though some animals died following barrel rotation as a result of its i.c.v. administration (in particular at doses higher than 10 nmol/rat). Nonetheless, these results suggest the potential use of hybrid compounds encompassing both opioid and neurotensin structural fragments in pain management. This highlights the enormous potential of synthetic neurotensin analogues as promising future analgesics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488486 | PMC |
| http://dx.doi.org/10.1016/j.apsb.2020.04.014 | DOI Listing |
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