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Lead time trajectory of blood-based protein biomarkers for detection of pancreatic cancer based on repeat testing.
Cancer Lett
January 2025
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 77030. Electronic address:
In the current study, we assessed whether repeated measurements of a panel of protein biomarkers with relevance to pancreatic ductal adenocarcinoma (PDAC) improves lead time performance for earlier detection over a single timepoint measurement. Specifically, CA125, CEA, LRG1, REG3A, THBS2, TIMP1, TNRFSF1A as well as CA19-9 were assayed in serially collected pre-diagnostic plasma from 242 PDAC cases and 242 age- and sex-matched non-case control participants in the PLCO cohort. We compared performance estimates of a parametric empirical Bayes (PEB) algorithm, which incorporates participant biomarker history, to that of a single-threshold (ST) method.
View Article and Find Full Text PDFExtending the translational science benefits model to implementation science for cancer prevention and control.
J Clin Transl Sci
November 2024
Center for Public Health Systems Science, Washington University, St Louis, MO, USA.
Introduction: There is increasing pressure on the federal research budget and shifting public opinions about the value of the academic enterprise. We must develop and apply metrics that demonstrate the broad benefits of research for health and society. The Translational Science Benefits Model (TSBM) measures the impact of large-scale translational science initiatives, such as the National Cancer Institute's Cancer Moonshot.
View Article and Find Full Text PDFA newly developed articulated through-the-scope traction device, TRACMOTION, has been used clinically for endoscopic submucosal dissection (ESD). However, there are few reports on the characteristics of this device and the lesion types for which it is most effective. Therefore, we evaluated its optimal use, efficacy, and safety clinically in animals.
View Article and Find Full Text PDFNeonatal gut microbiota and risk of developing food sensitization and allergy.
J Allergy Clin Immunol
December 2024
Laboratorie for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Laboratorie for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan. Electronic address:
Background: Food sensitization (FS) develops in early infancy and is a risk factor for subsequent food allergy (FA). Recent evidence suggests relationships of gut microbiota with FS and FA. However, little is known about the role of neonatal gut microbiota in the pathobiology of these manifestations.
View Article and Find Full Text PDFExploring the Psychological and Physiological Effects of Operating a Telenoid: The Preliminary Assessment of a Minimal Humanoid Robot for Mediated Communication.
Sensors (Basel)
November 2024
Presence Media Research Group, Hiroshi Ishiguro Laboratories, Deep Interaction Laboratory Group, Advanced Telecommunications Research Institute International (ATR), 2-2-2 Hikaridai, Seika-Cho, Soraku-Gun, Kyoto 619-0288, Japan.
Background: As the Internet of Things (IoT) expands, it enables new forms of communication, including interactions mediated by teleoperated robots like avatars. While extensive research exists on the effects of these devices on communication partners, there is limited research on the impact on the operators themselves. This study aimed to objectively assess the psychological and physiological effects of operating a teleoperated robot, specifically Telenoid, on its human operator.
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