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| http://dx.doi.org/10.1017/ice.2020.1224 | DOI Listing |
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View Article and Find Full Text PDFOutpatient Total Knee Arthroplasty Has Become More Frequent Since the Onset of the COVID-19 Pandemic Without an Increase in Early Post-Operative Complications.
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Department of Orthopaedic Surgery, Virginia Commonwealth University Health System, Richmond, VA, USA.
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Exposure to influenza A virus (IAV), respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) is well-known to increase the risk of pneumonia in humans. Type I interferon (IFN-I) is a hallmark response to acute viral infections, and alveolar macrophages (AMs) constitute the first line of airway defense against opportunistic bacteria. Our study reveals that virus-induced IFN-I receptor (IFNAR1) signaling directly impairs AM-dependent antibacterial protection.
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