A new sesquiterpene from mangrove endophytic fungus sp. GXNU-MA1.

A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives were isolated from the mangrove endophytic fungus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of was established. Compounds were evaluated for their anti-inflammatory activities against the nitric oxide (NO) production, and compounds showed moderate inhibitory activities with IC values ranging from 16.15 to 27.08 M.