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Open surgical treatment for giant presacral tailgut cyst - a case report.
S Afr J Surg
December 2024
Department of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, China.
Tailgut cyst is an exceedingly rare congenital anomaly originating from embryonic remnants of the tailgut. Owing to its asymptomatic nature in the early stages, it is prone to clinical misdiagnosis. We present a case of a 55-year-old female with initial symptoms manifesting as sacrococcygeal pain.
View Article and Find Full Text PDFDefining the contribution of human error to adverse events in a surgical service.
S Afr J Surg
December 2024
Department of Surgery, University of KwaZulu-Natal, South Africa.
Background: This study aimed to assess the contribution of human error to adverse events over 10 years in a single surgical department in South Africa.
Methods: A retrospective database analysis was undertaken to identify all adverse events, which were further assessed to identify which were error-associated.
Results: A total of 14 237 adverse events occurred between December 2012 and January 2023, of which 7 504 (52.
Ground-state pluripotent stem cells are characterized by Rac1-dependent Cadherin-enriched F-actin Complexes.
J Cell Sci
January 2025
Mechanobiology Institute, National University of Singapore, Singapore 117411, Republic of Singapore.
Pluripotent Stem Cells (PSCs) exhibit extraordinary differentiation potential and are thus highly valuable cellular model systems. However, while different PSC types corresponding to distinct stages of embryogenesis have been in common use, aspects of their cellular architecture and mechanobiology remain insufficiently understood. Here we investigated how the actin cytoskeleton is regulated in different pluripotency states.
View Article and Find Full Text PDFComplete Breakup of Liquids into Ultrafine Droplets by Grid Turbulence.
Nano Lett
January 2025
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Ultrafine droplets are crucial in materials processing and nanotechnology, with applications in nanoparticle preparation, water evaporation, nanodrug delivery, nanocoating, among numerous others. While the potential of turbulent gas flow to enhance liquid breakup is acknowledged, constructing turbulence-driven atomizers for ultrafine droplets remains challenging. Herein, we report the innovation of grid-turbulence atomization (GTA), which employs a rotating mesh to deliver liquid and an air knife to spray ultrafine droplets.
View Article and Find Full Text PDFSMARCB1/INI-1-Deficient sinonasal carcinoma demonstrates a poor prognosis but favorable clinical outcomes after PD-1/PD-L1 inhibitor therapy: A case series.
Sci Prog
January 2025
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Despite advances in multimodal cancer therapy, such as combining radical surgery with high-intensity chemoradiotherapy, for SMARCB1/INI-1-deficient sinonasal carcinoma (SDSC), the prognosis of patients remains poor. Immunotherapy is gaining increasing popularity as a novel treatment strategy for patients with SMARCB1/INI-1-deficient tumors. Herein, we report on the management of three patients with SDSC who received PD-1/PD-L1 inhibitor therapy as a part of multimodal therapy based on surgery and chemoradiotherapy.
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