AI Article Synopsis
- Oral mucositis (OM) is a serious side effect of cancer treatments that can impair quality of life and lead to therapy interruptions.
- Photobiomodulation (PBM) is being studied as a potential solution to promote faster healing and may help manage inflammation and microorganisms in the mouth.
- A pilot study found that PBM reduced harmful pro-inflammatory cytokines, increased beneficial anti-inflammatory cytokines, and improved the overall balance of the oral microbiome, especially in patients who responded well to the treatment.
Article Abstract
Introduction: Oral mucositis (OM) is a severe side effect in patients undergoing anticancer therapies, which negatively impacts on their quality of life often leading to either the interruption of the therapy. Photobiomodulation (PBM) is emerging as an effective strategy allowing a faster wound healing.
Objectives: This pilot study aims at verifying whether PBM modulates the inflammatory response in patients and its effect on the oral microbiome composition.
Materials And Methods: Buccal swabs were collected from four patients affected by OM, both on ulcerated and clinically healthy areas, before and on the last day of PBM therapy, as well as on the first day after treatment discontinuation. The concentration of 38 cytokines and the composition of oral microbiome were measured.
Results: Most of the pro-inflammatory cytokines were reduced, whereas anti-inflammatory cytokines resulted up-regulated by PBM. In addition, PBM influenced the composition of oral microbiome, by decreasing the amount of pathogenic species and promoting the growth of commensal bacteria. These changes were even more evident when separately analysing patients who clinically responded to PBM and the only patient who did not respond.
Conclusions: PBM reduces inflammatory burden in patients affected by OM and positively influences the composition of the oral microbiome.
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| http://dx.doi.org/10.1080/1354750X.2020.1825812 | DOI Listing |
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