Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity.

Chem Commun (Camb)

Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.

Published: September 2020

In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.

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http://dx.doi.org/10.1039/d0cc04759gDOI Listing

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