AI Article Synopsis
- The study focuses on a novel method for creating C-C bonds through the use of arylboronic acids to catalyze the reaction between 1,3-diketones or 1,3-ketoesters and secondary benzylic alcohols.
- This reaction yields high results, with up to 98% efficiency and produces water as the sole byproduct.
- Additionally, the method can be adapted for allylation using allyltrimethylsilane, achieving yields of up to 96%.
Article Abstract
The arylboronic acid catalyzed dehydrative -alkylation of 1,3-diketones and 1,3-ketoesters using secondary benzylic alcohols as the electrophile is reported, forming new C-C bonds (19 examples, up to 98% yield) with the release of water as the only byproduct. The process is also applicable to the allylation of benzylic alcohols using allyltrimethylsilane as the nucleophile (12 examples, up to 96% yield).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155392 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.0c02736 | DOI Listing |
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