The current study examined a predictive model of both universal factors (socioeconomic, neuroticism, and extraversion) and culturally specific factors (sense of community, trust, and self-construal) towards the well-being of Indonesians. A nationally representative sample (N = 929) was recruited across the nation to complete a survey in either online or offline format. The survey contained a measure of well-being as well as demographic, psychosocial, and cultural variables. Analysis via hierarchical multiple regression showed that both universal and cultural factors were associated with well-being in this Indonesian sample. In particular, once the cultural factors were added to the model, there were changes in universal factor effects to well-being. The finding of this study recognized the multidimensional model of well-being and supports the importance of evaluating well-being at the dimensional level to allow for an exploration of the nuanced relationship between distinct indicators and facets of well-being. The theoretical implications of these results and future directions were also discussed in this study.
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Top Stroke Rehabil
January 2025
Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: The successful transition of stroke patients from hospital to home relies on the preparedness of caregivers. Assessing this preparedness is crucial, but existing tools need adaptation and validation for Iranian caregivers.
Objectives: This study aimed to translate, culturally adapt, and validate the Persian version of the "Preparedness Assessment for the Transition Home After Stroke" (PATH-s) for use among Iranian caregivers of stroke survivors.
Clin Cardiol
January 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Background: Parkinson disease (PD) and cardiovascular diseases (CVD) present significant health burdens, particularly among older adults. Patients with PD have an elevated risk of CVD-related mortality. Analyzing mortality trends in this population may help guide focused interventions.
View Article and Find Full Text PDFCirc Cardiovasc Qual Outcomes
January 2025
Department of Medicine, Cardiovascular Division, University of Virginia Health, Charlottesville, Virginia, USA. (P.F.R.L., C.C.S.).
Arterioscler Thromb Vasc Biol
January 2025
British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, United Kingdom. (M.W., M.F., R.O., L.S., M.M., C.M.S.).
Background: The ECM (extracellular matrix) provides the microenvironmental niche sensed by resident vascular smooth muscle cells (VSMCs). Aging and disease are associated with dramatic changes in ECM composition and properties; however, their impact on the VSMC phenotype remains poorly studied.
Methods: Here, we describe a novel in vitro model system that utilizes endogenous ECM to study how modifications associated with age and metabolic disease impact the VSMC phenotype.
World J Gastrointest Oncol
January 2025
Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
Background: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with high morbidity and mortality, and easy to develop resistance to chemotherapeutic agents. Telomeres are DNA-protein complexes located at the termini of chromosomes in eukaryotic cells, which are unreplaceable in maintaining the stability and integrity of genome. Telomerase, an RNA-dependent DNA polymerase, play vital role in telomere length maintain, targeting telomerase is a promising therapeutic strategy for cancer.
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