Purpose: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts.
Methods: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research.
Results: SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma.
Conclusion: Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505486 | PMC |
| http://dx.doi.org/10.1007/s10815-020-01952-x | DOI Listing |
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