AI Article Synopsis
- Atropine is identified as the most effective treatment for slowing down progressive myopia in children and this study assesses its effectiveness over a 3-year clinical period.
- The study involved 124 children, with adjustments made to the atropine dosage based on individual responses to treatment, highlighting a significant portion of participants remained on the medication throughout the study.
- The results indicate that those treated with atropine 0.5% experienced reduced myopia progression, supporting its use as a viable option for managing high myopia risk in children.
Article Abstract
Background: Atropine is the most powerful treatment for progressive myopia in childhood. This study explores the 3-year effectiveness of atropine in a clinical setting.
Methods: In this prospective clinical effectiveness study, children with progressive myopia ≥ 1D/year or myopia ≤ -2.5D were prescribed atropine 0.5%. Examination, including cycloplegic refraction and axial length (AL), was performed at baseline, and follow-up. Outcome measures were spherical equivalent (SER) and AL; annual progression of SER on treatment was compared with that prior to treatment. Adjustments to the dose were made after 1 year in case of low (AL ≥ 0.3 mm/year) or high response (AL < 0.1 mm/year) of AL.
Results: A total of 124 patients were enrolled in the study (median age: 9.5, range: 5-16 years). At baseline, median SER was -5.03D (interquartile range (IQR): 3.08); median AL was 25.14 mm (IQR: 1.30). N = 89 (71.8%) children were persistent to therapy throughout the 3-year follow-up. Median annual progression of SER for these children was -0.25D (IQR: 0.44); of AL 0.11 mm (IQR: 0.18). Of these, N = 32 (36.0%) had insufficient response and were assigned to atropine 1%; N = 26 (29.2%) showed good response and underwent tapering in dose. Rebound of AL progression was not observed. Of the children who ceased therapy, N = 9 were lost to follow-up; N = 9 developed an allergic reaction; and N = 17 (19.1%) stopped due to adverse events.
Conclusion: In children with or at risk of developing high myopia, a starting dose of atropine 0.5% was associated with decreased progression in European children during a 3-year treatment regimen. Our study supports high-dose atropine as a treatment option for children at risk of developing high myopia in adulthood.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785025 | PMC |
| http://dx.doi.org/10.1038/s41433-020-1122-7 | DOI Listing |
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