AI Article Synopsis
- Endometrial cancer is a prevalent condition in older women and often occurs alongside other health issues, necessitating a team-based treatment approach for advanced cases.
- Recent insights into the cancer's molecular characteristics have led to new opportunities for targeted therapies, with recommendations based on established clinical practices aimed at incorporating these findings into diagnosis and treatment.
- The diagnosis involves assessing hormone receptors and DNA mismatch repair status, and treatment varies depending on the histological type, which can involve chemotherapy, hormone therapy, or immunotherapy for certain patients.
Article Abstract
Endometrial cancer is a common cancer in older women and is often associated with comorbidities. Management of metastatic disease and/or relapse requires a multidisciplinary approach. Recent advances in the understanding of oncogenesis and molecular classification of endometrial cancers offer new therapeutic perspectives. These first recommendations, established following the methodology of Nice-Saint-Paul recommendations for clinical practice (RPC), aims to integrate molecular advances in diagnostic and therapeutic management. In 2020, the histological diagnosis of endometrial cancer is based on morphology and immunohistochemistry, including at least p53, oestrogen and progesterone receptors. Deficiency in the DNA mismatch repair system (MMR) must be assessed in all advanced endometrial tumors for oncogenetic and theranostic purposes. It can be sought initially by an analysis in immunohistochemistry with the 4 markers (MLH1, MSH2, MSH6, PMS2). Medical treatment depends on histological type, presence of hormone receptors and patient's profile to refer to chemotherapy (carboplatin-paclitaxel) or hormone therapy (for example of the progestogen type); in the event of MMR-deficiency, immunotherapy trial is the best option. As part of overall management of advanced endometrial cancer, radiotherapy (and surgery in rare cases) must be discussed, in particular in the event of loco-regional only relapse or oligometastatic disease.
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| http://dx.doi.org/10.1016/j.bulcan.2020.06.006 | DOI Listing |
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